Actifed Day and Night - box of 12 day tablets (white) and 4 night tablets (blue)

Presentation of the medicine ACTIFED RHUME DAY AND NIGHT

This medicine comes in two different tablets: the white tablets for daytime use contain a decongestant vasoconstrictor (pseudoephedrine) and paracetamol (antipyretic and analgesic); the blue tablets, to be taken in the evening, contain an antihistamine with a drying effect on nasal secretions and paracetamol.

Composition of the medicine ACTIFED RHUME JOUR ET NUIT

Active ingredients: Diphenhydramine hydrochloride, Paracetamol, Pseudoephedrine hydrochloride Excipients: Corn starch, Croscarmellose Na salt, Crospovidone, Purified water, Hyprolose, Hypromellose, Indigotine, Magnesium stearate, Opaspray, Povidone, Propylene glycol, Sodium carboxymethyl starch, Titanium dioxide, Modified corn starch, Stearic acid

Contraindications of the medication ACTIFED RHUME DAY AND NIGHT

This medication should not be used in the following cases:

• - hepatic insufficiency ;

• - risk of angle-closure glaucoma;

• - risk of urine blockage (prostate adenoma);

• - high blood pressure not controlled by specific treatment;

• - severe coronary insufficiency;

• - history of convulsions;

• - history of cerebrovascular accident;

• - in association with a non-selective MAOI antidepressant or for at least 15 days after taking it;

• - in combination with another decongestant vasoconstrictor or a vasoconstrictor containing any of the following: bromocriptine, pergolide, lisuride, cabergoline, ergotamine or dihydroergotamine;

• - children under 15 years of age;

• - breast-feeding.

Caution

Pseudoephedrine can cause acute glaucoma in susceptible individuals: red, hard, painful eye with blurred vision. Urgent consultation with an ophthalmologist is necessary.

Decongestant vasoconstrictors may increase the heart rate (tachycardia) and cause palpitations and nausea. If these side effects are too severe, treatment should be discontinued.

They may also be responsible for rare complications (convulsions, hallucinations, abnormal agitation), especially if the dosage is excessive. Respect the recommended dose.

It is preferable to seek medical advice before using this medicine in cases of hyperthyroidism, heart disease, diabetes, mental disorders, renal failure and in the elderly, especially in cases of chronic constipation, tendency to dizziness or low blood pressure.

Paracetamol is present alone or in combination with other substances in many medicines: make sure you do not take several medicines containing paracetamol at the same time, as taking them together can lead to an overdose that can be toxic to the liver.

Avoid alcoholic beverages: increased risk of drowsiness.

This medication contains an antihistamine which may cause drowsiness, sometimes severe in some people. This drowsiness may be increased by taking alcohol or other sedative medications. Make sure that you tolerate it well when taking it for the first time, before driving or operating dangerous machinery.

Sportsmen: this medicine contains a substance considered to be a stimulant (phenylephrine, pseudoephedrine or synephrine) which is included in the 2004 monitoring programme of the Ministry of Youth and Sport. It may be tested in the urine of athletes to detect possible misuse.

Interactions of ACTIFED RHUME JOUR ET NUIT with other substances

This medicine should not be used in combination with

• - a non-selective MAOI type antidepressant(MARSILID): a period of at least 15 days must be observed between taking these 2 drugs;

• - another oral vasoconstrictor (phenylephrine, pseudoephedrine, methylphenidate) or a nasal vasoconstrictor (naphazoline, oxymetazoline, ephedrine or tuaminoheptane sulfate): risk of hypertensive crisis

It may interact with vasoconstrictors used in Parkinson's disease (bromocriptine, pergolide, lisuride, cabergoline) or in migraine (ergotamine, dihydroergotamine, methysergide) or with selective A MAOIs (moclobemide)

Inform your doctor or pharmacist if you are taking any other medication with atropine or sedative effects (tranquillisers, sleeping pills, certain cough or pain medications containing opiates, antidepressants, neuroleptics, etc.).

In case of treatment with an oral anticoagulant and paracetamol at maximum doses (4 g per day) for at least 4 days, increased monitoring of the anticoagulant treatment may be necessary.

Fertility, pregnancy and lactation

Pregnancy:

Due to the presence of pseudoephedrine, the use of this drug is not recommended in pregnant women.

Breast-feeding: